Graduate School Life Science Munich

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Prof. Thomas Lahaye

Analysis and application of transcription-activator like effector proteins

Plant pathogenic bacteria of the genus Xanthomonas inject Transcription-Activator Like Effector proteins (TALEs) into plant cells. Upon injection, TALEs translocate to the plant nucleus, bind to defined DNA motifs and activate expression of the downstream host genes. TALE-mediated activation of plant promoters in most cases favours disease progression but triggers in some plant genotypes activation of the plant immune system. One focus of our group is to clarify the molecular basis of how TALes activate the plant immune system. A second focus is the biotechnological exploitation of the TALE DNA binding domain that can be modified to target any desired nucleotide sequence. For more information please visit our website under: