Our research centers on the total synthesis of complex natural products and rationally designed molecular probes and their application to biological problems, especially in neuroscience. A large part of our research program is dedicated to the synthesis and biological evaluation of natural products - that is biologically active metabolites with relatively low molecular weights. We are convinced that the vast majority of natural products have not yet been found and that a wealth of interesting chemistry and biology awaits discovery. As synthetic organic chemists, we are intrigued by the structural beauty and functional sophistication of natural products. Through total synthesis, we gain insight into their structure/activity relationships and biosynthetic origin. In addition, the total synthesis of complex natural products provides an ideal platform for the invention or discovery of new synthetic methodology or the validation of modern reactions in a complex environment.