Graduate School Life Science Munich
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Dr. Anne-Kathrin Classen (Cell Biology, Epigenetics)

Dr. Anne-Kathrin Classen

Proliferation, regeneration and morphogenesis of epithelial tissues.

Epithelial tissues cover organ surfaces throughout our body and fulfill crucial functions such as protection, secretion and absorption. Our lab investigates epithelia of the Drosophila model system to better understand which cellular mechanisms regulate proliferation, morphogenesis and regeneration of these tissues.
We employ fly models of tissue regeneration and of cancer to investigate how cellular responses to tissue stress are coordinated at the level of signaling and at the level of chromatin. Our work aims to understand how epigenetic plasticity is generated to promote regenerative proliferation, or under pathological conditions, cancerous growth.
A second line of investigation in the lab studies how epithelial tissues acquire diverse shapes as a consequence of cytoskeleton dynamics, cell-cell adhesion and cell-matrix interactions. We analyze the regulation of these cellular components to reveal biomechanical principles that give rise to geometries of epithelial cells and therefore underlie the physical parameters of epithelial morphogenesis.


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